Trepanations in non-adults of the 16th to 18th C. The osteological series of the Church of the Assumption of Valdepeñas (Ciudad Real, Spain).

OBJECTIVE: To investigate the presence of trepanations in an early Modern Age, skeletal collection documented in medical treatises but infrequently reported in osteological collections. MATERIALS: Analyses were conducted on 387 non-adult crania from the ossuary in the church of the Assumption of Valdepeñas (16th - 18th C.), Ciudad Real, Spain. METHODS: All complete or semi-complete crania of non-adults (aged 3-20 years) were macroscopically examined. RESULTS: Trepanation was detected in two adolescents aged 14 and 20 years; no evidence of their survival was observed. CONCLUSIONS: These findings suggest that trepanation was carried out in rural areas as Valdepeñas in the 16th-18th centuries, where the selection of instruments indicates knowledge of contemporaneous medical treatises. SIGNIFICANCE: The present study provides new data on trepanation and how it was performed in adolescents during this period. LIMITATIONS: Understanding the motive for these interventions is highly challenging in the absence of bone lesions, and their occurrence is likely underestimated due to the scant research in skeletal remains from the early Modern Age. SUGGESTIONS FOR FUTURE RESEARCH: Further palaeopathological analyses of osteological collections from this period will provide more information about how this surgical technique was perfected.

Cranial Surgery in Italy During the Bronze Age.

Skull vault trepanation is a surgical practice that has been found in prehistoric human remains. We carried out a review of the literature on cranial trepanations performed during the Bronze Age in Italy. In total, 19 individuals, most of whom were adult males, with 33 trepanations have been reported, including a new specimen from the Italian Middle Bronze Age (1700-1400 BCE), found at Grotta della Monaca (Calabria). The evidence of cranial trepanations is geographically uneven across Italy, with the highest occurrence in Sardinia. Several trepanation techniques were applied in Italy during this period, where the drilling method was the most common solitary technique utilized. The survival rate of 79.3% in Bronze Age Italy suggests that trepanation was carried out with remarkable success. This analysis gives further insight into ancient human behavior and enhances our knowledge of surgical practices in antiquity, shedding light on the origins of neurosurgery.

Legacies of Neurosurgery and its Implications on Global Neurosurgery Today.

Trephination, the practice of boring a hole in the skull, is one of the oldest surgical procedures performed by and on humans. Fossil records show evidence of trephined skulls on separate continents throughout ancient history. Even more remarkably, fossils show that ancient humans actually survived the procedure, some more than once. Ancient mythologies and texts provide context to the fossil record, indicating that trephination was performed some of the time for medical indications, including traumatic head injury and intractable neurologic conditions. In the modern day, traumatic brain injury accounts for a significant percentage of the overall global burden of disease and its incidence is disproportionately increasing in low- and middle-income countries. In critical situations, neurosurgical intervention may be indicated. The burr hole procedure, or trephination, was identified as an essential surgical procedure that all first-level hospitals should be able to perform; however, there exists a dramatic lack of access to neurosurgical specialists and care globally, especially among low- and middle-income countries. Task-shifting/sharing is one paradigm that may be used effectively to broaden access to this life-saving procedure but it is at the moment a contested practice.

Trepanation of the Outer Table as a Treatment for Scalping Injuries: Historical Perspective and Modern Applications.

Complex cranial wounds represent complex surgical problems. In modern times, these are mostly due to accidental trauma. During the period of the American Frontier, violent scalping was a common practice. Innovative techniques were utilized to improve outcomes for this condition that still have relevance in today's practice. We provide a historical perspective with vignettes that identify survivors of violent scalping from the American Frontier as well as the surgical techniques used to treat them. The techniques identified were then modified for modern practice and applied to a complex cranial wound. A review of primary and secondary historical sources was carried out. Nine separate incidences of violent scalping were identified from this period. Successful treatment relied on exposure of the diploe leading to granulation tissue formation and eventual scalp coverage. This was accomplished as a byproduct of the violence of the scalping or as an application of the technique first described by Augustin Belloste in 1696. Application of this technique in a modern setting may allow for improved wound healing. Trepanation of the outer table to aid in healing and closure of complex cranial wounds has a long history of successful practice and can be successfully applied to modern practice.

The history of bone marrow in orthopaedic surgery (part I trauma): trepanning, bone marrow injection in damage control resuscitation, and bone marrow aspiration to heal fractures.

PURPOSE: One of the oldest procedures performed by man is trepanning of the bone and yet it was only in the last 40 years that bone marrow aspiration has been used to treat nonunion disorders. MATERIAL AND METHODS: These advances were possible due to improvements in instruments and in techniques to make holes in the bone, an history that began with skull trephinations around 8000-10,000 years ago, and continued with sternum bone marrow injection for trauma resuscitation in the beginning of the twentieth century; this procedure had improved at the beginning of the twenty-first century to allow pelvis bone marrow aspiration for the treatment of nonunion. RESULTS: Trephined skulls from antiquity have been found in many parts of world, showing that trephining was ancient and widespread. Beginning with Neolithic period and the pre-Columbian Andean civilizations, the authors have traced the development of this surgical skill by describing the various surgical tools used to perform holes in the skull. These tools (trephines or trepan) were proposed at the end of the nineteenth century to study the bone marrow. At the beginning of the twentieth century, the sternum became the center of interest for the "in vivo" study of the bone marrow and the fluid injection in the sternum's bone marrow was described for resuscitation from shock during the World War II. With the introduction of plastic catheters and improved cannulation techniques, the need for intraosseous infusion as an alternative route for intravenous access diminished and sometimes abandoned. However, during the mid-1980s, James Orlowski allowed renaissance of the use of intraosseous infusion for paediatric resuscitation. Since then, this technique has become widespread and is now recognized as an alternative to intravenous access in adult emergencies; particularly, the intraosseous access has received class IIA recommendation from the Advanced Trauma Life Support program supported by the American College of Surgeons Committee on Trauma and bone marrow infusion is now recommended for "Damage Control" resuscitation. Although the pelvis bone contains half of the body's marrow volume, it was only in 1950 that the pelvis was proposed as a source for bone marrow aspiration and bone marrow-derived mesenchymal stem cells to improve healing of fractures. CONCLUSION: It will be many years before doing holes in the bone as orthopaedic trauma procedure will be relegated to the annals of history.

Trepanation in archaic human remains - characteristic features and diagnostic difficulties.

Three trepanned skulls originated from a medieval archeological site at St. Pantelejmon Church, located in Serbia, all showing characteristic depressions and perforations of the vault of the skull from trepanning. Trepanation refers to the process of creating a defect in the skull by drilling, cutting or scraping and is one of the oldest known surgical procedures. Anthropological assessment of possible cases of trepanation in archaic material is complicated by a differential diagnosis that includes both congenital/developmental lesions such as parietal fenestrae, and acquired conditions such as trauma, infection and malignancy.

A Note About the Ancestral Origin of Abu Al Husain Ibn Abdullah Ibn Sina, Avicenna (980-1037 CE).

Avicenna, a great physician and polymath, made a tremendous contribution to our present-day medicine. His ancestral origin has been the subject of debate. In this short and concise article, we have endeavored to trace his ancestral roots and bring to light his exact origin and nationality.

Enfermedades médicas, trepanación y cirugía de emergencia durante el sitio de Gibraltar (1779-1783). Las operaciones de Joaquín de Villalba (1752-1807) / Medical diseases, trepanning, and emergency surgery during the 1779-1783 Siege of Gibraltar: the surgeries of Joaquín de Villalba (1752-1807)

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Frank Clifford Rose Memorial Lecture: The tale of three trephines: Surgeons and their surgical-instrument makers in Britain, France, and America in the nineteenth century.

Trephines and trepanning date to ancient times, but a "modern" form of instruments was codified by the seventeenth century. This did not preclude efforts to "improve" the trephine in the late-eighteenth and nineteenth centuries. Surgeons and instrument makers in Britain (Jardine and Savigny), France (Thomson and Charrière), and America (Galt and Otto & Reynders) endeavored to make the trephine safer and more precise. In exploring their interactions, this presentation shows the evolving role of the instrument makers not only as fabricators of tools, but as creative design collaborators of surgeons and physicians.

New Evidence of Prehistoric Neurosurgery in Italy: The Case of Castello Del Tartaro.

Archaeological evidence of trepanation during the European Bronze Age is numerous and testifies a wide application of neurosurgical practices during prehistory. In some particular cases, trepanation may be associated with other peculiar evidence concerning funerary practices. The aim of this paper is to present the case of a woman from the Recent Bronze Age site of Castello del Tartaro (Verona, Italy), who was buried in a prone position and whose skeletal remains presented evidence of probable frontal trepanation. The association between a deviant burial and trepanation could be of interest in better understanding the history and perception of neurosurgical practices during prehistory.

Vestiges of autopsies and surgical procedures in the "Baron von Asch" skulls of the Blumenbach Skull Collection in Göttingen.

Some of the oldest specimens from the Blumenbach Skull Collection were provided by Baron Georg Thomas von Asch (1729-1807) from Saint Petersburg, who was staff-surgeon general of the Imperial Russian Army, and Privy Council for Empress Catherine II. The 63 human skulls, which originate from all over the Russian Empire, provide the basis of a new anthropological and palaeopathological investigation. The distribution of age-at-death and sex of the skull sample reveals that most of the individuals were young adult males. Cut marks, as well as remnants of soft tissue, deliver information about the preparation of the skulls. Some skulls were craniotomised. The way the craniotomies were performed suggests that they mostly were carried out for autoptic reasons. Two of the skulls show trepanation openings from a circular cranial trepan. One of these individuals obviously died during or soon after the surgical event, while the other one survived the procedure. The interpretation of the results of the anthropological and palaeopathological analysis gives an interesting insight into the character of these collection specimens. Furthermore, it reveals essential information about autoptic and surgical practice during the second half of the 18th century AD.

The Siberian Lancet: One More Possible Innovative Example of Scalpel's Contribution to the Evolution of Surgical Anatomy and Neurosurgery.

BACKGROUND: Several primitive scalpels were used since the eve of surgical procedures. Numerous bronze knifes discovered in the Altai mountains region from the Xiongnu-Xianbei-Rouran period mold a hypotheses for a possible medical use. METHODS: On-sight archaeologic excavation brought into light the tools in question. RESULTS: Knifes, similar to modern lancets, were unearthed alongside with a series of skulls demonstrating signs of trepanation. CONCLUSIONS: Strong indications imply that those cutting tools, except for domestic usage, were one more example of scalpel's contribution to the evolution of surgical anatomy and neurosurgery.

Linear Cutting Trepanation in Italy: A Unique Case from Hellenistic Sicily (Third Century BC).

During the archaeological excavations conducted in the Hellenistic necropolis discovered in Messina (Sicily, Italy) dating back to the 3rd century BC., a skeleton showing evidence of cranial traumas and surgical intervention was found. The skull, belonging to a young adult male, presented signs of 4 head injuries produced by both blunt and sharp-edged instruments. The first 2 lesions, located on the frontal bone, were produced by blunt blows and showed signs of long-term survival. The third lesion, located on the inferior portion of the right parietal, suggests a perimortem nonpenetrating linear cut likely caused by a blade instrument. Finally, a rectangular bone loss is visible on the left parietal bone, involving the full cranial thickness with well-delimited cutting edges and no sign of a reparative process. This injury can be interpreted as the result of a trepanation, performed with the technique defined as "linear cutting" and obtained through 4 linear incisions in parallel pairs intersecting at the right angles. The trepanation is likely related to the multiple head injuries exhibited by the patient, who unfortunately did not survive the surgical intervention. Trepanation in Italy has been largely attested since Prehistoric times, but the case from Messina represents the first evidence of neurosurgical intervention performed through the linear cutting technique in the Italian context and the second case in the whole of Europe. This technique might have been imported in Sicily during the Hellenistic period from the Near East, where it is clearly attested.